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Measurement of absolute blood flow velocity in outflow tract of HH18 chicken embryo based on 4D reconstruction using spectral domain optical coherence tomography

机译:基于光谱域光学相干层析成像的4D重建技术测量HH18鸡胚流出通道中的绝对血流速度

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摘要

The measurement of blood-plasma absolute velocity distributions with high spatial and temporal resolution in vivo is important for the investigation of embryonic heart at its early stage of development. We introduce a novel method to measure absolute blood flow velocity based on high speed spectral domain optical coherence tomography (OCT) and apply it to measure velocities across the heart outflow tract (OFT) of a chicken embryo (stage HH18). First, we use the OCT system to acquire 4D 
[(x,y,z) + t] images of the OFT in vivo. Second, we reconstruct the 4D microstructural images and obtain the orientation of the OFT at its maximum expansion, from which the centerline of the OFT is calculated based on the OFT boundary segmentation. Assuming flow is parallel to the vessel orientation, the obtained centerline indicates the flow direction. Finally, the absolute flow velocity is evaluated based on the direction given by the centerline and the axial velocity obtained from Doppler OCT. Using this method, we compare flow velocity profiles at various positions along the chicken embryo OFT.
机译:在体内具有高时空分辨率的血浆绝对速度分布的测量对于研究胚胎心脏在其早期阶段是重要的。我们介绍了一种基于高速光谱域光学相干断层扫描(OCT)的绝对血流速度测量新方法,并将其应用于测量鸡胚心脏流出道(OFT)的速度(HH18级)。首先,我们使用OCT系统在体内获取OFT的4D [(x,y,z)+ t]图像。其次,我们重建4D微结构图像,并获得OFT在其最大扩展处的方向,然后根据OFT边界分割从中计算出OFT的中心线。假设水流平行于容器方向,则获得的中心线表示水流方向。最后,根据中心线给出的方向和从多普勒OCT获得的轴向速度评估绝对流速。使用这种方法,我们比较了沿鸡胚OFT在各个位置的流速分布。

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